Droplet Generation System (SDG2000)



Droplet Formation

Live-cell Encapsulation

Live-cell Encapsulation

Oil Droplet Encapsulation

Oil Droplet Encapsulation

Droplet Formation

Droplet Formation

Alginate Microbeads 250um

Key Features

  • Low cost, disposable and contamination-free (sterilized) microfluidic chips for droplet generation
  • Highly uniform microbeads (CV 1-3%)
  • Droplet Dimension Adjustable by setting the chip tip diameter, flow rate, vibration frequency, etc.
  • 100% bio-compatible without usage of oil or surfactant
  • Bio-safety Cabinet Compatible
  • Integrated camera available for real-time droplet observation
  • High throughput, i.e.>1000 droplets/second
  • Easy to scale up
Droplet Generation System Details

System Details

Applications of S-droplet SDG 2000 (GMP compliant)

Live-cell

  • Encapsulation for disease treatment.
  • Microdroplets to microbeads for bio-encapsulation.
  • 100% bio-compatible with out usage of surfactant.
  • Easy cleaning process.
  • GMP compliant (optional).

Drug/Bio-drug

  • Encapsulation for pharmaceutical industry.
  • High throughput, i.e. >1000 droplet per second.
  • Droplet charging process to prevent droplet coalescence.
  • Easy to scale up.

Oil Encapsulation

  • Encapsulation for cosmetic industry.
  • Droplet size in different dimensions (120-800μm).
  • Flow-rate, chip tip size, vibration frequency adjustable.
  • Integrated camera.

Essence

  • High uniform microbeads (CV 1-3%).
  • Low-cost, disposable and sterilized microfluidic chips.
  • Real-time observation.
  • Taste masking for food and Traditional Chinese Medicine.

General Specifications

Droplet Information
Vibration FrequencyUp to 5kHz
Changing VoltageUp to 2500 Volts
Available flow exit Diameter70μm, 120μm, 170μm & 250 μm; Customized dimensions upon request
Stroboscopic LightingAutomatic synchronized with vibration frequency
StirrerProgram controlled
High Speed CameraProgram controlled; Position adjustable
Droplet diameter120-800μm (material dependent)
Hardware Interface and Setting
Interface to ComputerUSB
Syringe Size20mL (recommended)
Flow RateUp to 500mL/hr (material dependent)
Overall
Dimension (LxWxH)~400mmx500mmx600mm
Weight~20Kg
Working Temperature~25°C
Voltage~110 or ~230V (50-60Hz)
Power~100W


Product Q & A



1. For oil droplet generation, does it apply to different oil or do I have to stick to a specific kind of oil.


[A] It applies to different oil as long as its viscosity is less than 100 cps. However the wetting of our chip tip/nozzle by different oil will be quite different and this will lead to different droplet formation conditions. Please let us know what types of oil preferred and we may do a testing first for the droplet formation.



2. Does it still generate droplets if we add surfactants?


[A] Our chip tip/nozzle is polycarbonate. Surfactants will affect droplet formation and thus it is recommended to let us know the surfactants (as well as its concentration) and arrange a test run. Besides, normally the surfactants are only added in the aqueous liquid. So if oil droplets are formed, you will need to add the surfactants in the collection bath, meaning the surfactants will not affect the droplet formation of the oil.



3. How long can these droplets keep stability (no coalescence) without surfactant?


[A] The droplet formation is single phase that means droplets are formed in air and then can be collected in oil or cross-linked by cross-linker. The droplets can be kept stable without coalescence typically for a few hours (surfactants and oil dependent). Again, it will be better for us to know your preferred droplet type so we can test first before advise more accurate data on the stability.



4. According to the general specification online, the droplet size is 120-800 µm. Is this a range regardless of variations in tip, flow rate, frequency, etc.?


[A] No. The optimized droplet formation parameter is affetced by solution viscosity, tip diameter, solution wetting condition on polycarbonate and usually only one optimized parameter can be obtained for one type of tip. The user can vary flow rate and frequency a bit around the optimized parameters. The droplet diameter can be accurately determined from flow rate and frequency. The software coming with the system helps the user to do this setup.


Most importantly, we will test the your material (should be common materials) before shipping out. This will be part of our service for quality assurance.



5. Can you make droplets tht are about 10 microns in diameter?


[A] For droplets with the size of 10 microns in diameter, we are still able to make them but using a different setup of the instrument. This is called “Micron-vaporization System” because when the droplets in such a small size are formed in the air, the droplets are likely to suspend or float in the air and become vapour. So the collection of the droplets into the collection bath may be challenging. We will need your input on the downstream application to customize a system.


It's suggested to let us know your intended application for the 10 micron droplets. Depending on your specific application, we will be glad to work together with you and deliver the applicable system for your needs.


Actually we have good reasons to set our standard system (SDG2000 Droplet Generator) for ~ 100-micron level droplets:

1. The energy level to generate the pressure drop to create small-size droplets (micron or sub-micron level) will be extremely high.

2. If using 2-phase flow in microfluidic channels to create the small-size droplets, the flow resistance will become extremely high and also the throughput will be much lower than single phase flow that we are using now.



That’s why our standard system is able to generate highly uniform droplets with good scaling-up capabilities.



6. May I get a quote for this instrument please?


[A] Please email us for a quotation: sales@airekacells.com.